发明授权
- 专利标题: 1,3-dihydroxy substituted phenylamide glucokinase activators
- 专利标题(中): 1,3-二羟基取代苯酰胺葡糖激酶活化剂
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申请号: US12663807申请日: 2008-06-11
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公开(公告)号: US08222285B2公开(公告)日: 2012-07-17
- 发明人: Sean Chen , Peter T. W. Cheng , Rebecca A. Smirk
- 申请人: Sean Chen , Peter T. W. Cheng , Rebecca A. Smirk
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Burton Rodney; Gary D. Greenblatt; Maureen S. Gibbons
- 国际申请: PCT/US2008/066510 WO 20080611
- 国际公布: WO2008/154563 WO 20081218
- 主分类号: A01N43/78
- IPC分类号: A01N43/78 ; A61K31/425
摘要:
Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R2 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or NR4; R3, R4, and R5 are as defined herein; R8 is aryl, heteroaryl, —PO(OR9)(OR10), —PO(OR9)R10 or —P(O)(R9)R10 (wherein R9 and R10 are as defined herein)/R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
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