Invention Grant
US08222297B2 Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents
有权
与DNA亲和性分子或水溶性芳环连接的苯胺或苯酚芥末及其作为癌症治疗剂的用途
- Patent Title: Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents
- Patent Title (中): 与DNA亲和性分子或水溶性芳环连接的苯胺或苯酚芥末及其作为癌症治疗剂的用途
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Application No.: US12008512Application Date: 2008-01-11
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Publication No.: US08222297B2Publication Date: 2012-07-17
- Inventor: Tsann-Long Su , Ting-Chao Chou
- Applicant: Tsann-Long Su , Ting-Chao Chou
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: VLP Law Group LLP
- Main IPC: A61K31/17
- IPC: A61K31/17 ; C07C275/40
Abstract:
New aniline or phenol N-mustards linked to DNA-affinity carriers (such as 9-anilinoacridines, acridines and quinolines), aminobenzamides or aminophenol ethers by a urea, carbamic acid, carbanic acid ester, hydrazineurea, hydrazinecarbamic acid ester, phenoxyurea, phenoxycarbamic acid ester linkage with improved chemical stability and anti-tumor therapeutic efficacy are provided.
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