Invention Grant
- Patent Title: Diagnostic imaging agents with MMP inhibitory activity
- Patent Title (中): 具有MMP抑制活性的诊断显像剂
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Application No.: US10544945Application Date: 2004-02-10
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Publication No.: US08231858B2Publication Date: 2012-07-31
- Inventor: Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Mendizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodo Levkau , Stefan Wagner , Hans-Jörg Breyholz , Klaus Kopka
- Applicant: Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Mendizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodo Levkau , Stefan Wagner , Hans-Jörg Breyholz , Klaus Kopka
- Applicant Address: GB Little Chalfont
- Assignee: GE Healthcare Limited
- Current Assignee: GE Healthcare Limited
- Current Assignee Address: GB Little Chalfont
- Priority: GB0302891.7 20030210; GB0307524.9 20030401
- International Application: PCT/GB2004/000524 WO 20040210
- International Announcement: WO2004/069365 WO 20040819
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14

Abstract:
The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
Public/Granted literature
- US20070071670A1 Diagnostic imaging agents with mmp inhibitory activity Public/Granted day:2007-03-29
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