公开(公告)号：US08231858B2

公开(公告)日：2012-07-31

申请号：US10544945

申请日：2004-02-10

申请人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Mendizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodo Levkau ,  Stefan Wagner ,  Hans-Jörg Breyholz ,  Klaus Kopka

发明人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Mendizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodo Levkau ,  Stefan Wagner ,  Hans-Jörg Breyholz ,  Klaus Kopka

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K51/0497

摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

摘要翻译： 本发明涉及诊断成像领域。 具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。 本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。 本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。 本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。 本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。

公开(公告)号：US20070071670A1

公开(公告)日：2007-03-29

申请号：US10544945

申请日：2004-02-10

申请人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Medizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodu Levkau ,  Stefan Wagner ,  Hans-Jorg Breyholz ,  Klaus Kopka

发明人： Anthony Storey ,  Julie Davis ,  Sally-Ann Ricketts ,  Marivi Medizabal ,  Alan Cuthbertson ,  Joseph Arukwe ,  Kirsty Heywood ,  Ian Wilson ,  Duncan Wynn ,  Michael Schafers ,  Bodu Levkau ,  Stefan Wagner ,  Hans-Jorg Breyholz ,  Klaus Kopka

IPC分类号： A61K51/00 ,  C07D401/02

CPC分类号： A61K51/0497

摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

摘要翻译： 本发明涉及诊断成像领域。 具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。 本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。 本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。 本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。 本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。

公开(公告)号：US20060222593A1

公开(公告)日：2006-10-05

申请号：US10469801

申请日：2002-03-01

申请人： Alan Cuthbertson ,  Marivi Mendizabal ,  Mark Dixon ,  Anthony Storey ,  Edward Bacon ,  Vinay Desai ,  Sudahkar Kasina ,  Henry Wolfe

发明人： Alan Cuthbertson ,  Marivi Mendizabal ,  Mark Dixon ,  Anthony Storey ,  Edward Bacon ,  Vinay Desai ,  Sudahkar Kasina ,  Henry Wolfe

IPC分类号： A61K49/00 ,  C07K14/47

CPC分类号： C07K7/06 ,  A61K51/088 ,  C07K14/245 ,  G01N33/57419

摘要： A peptide-chelate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaccutical composition comprising the metal complex is provided, which is suitable for the diagnostic imaging of colorectal cancer. Also provided for in the invention is a kit for the preparation of the radiopharmaceutical preparation.

摘要翻译： 公开了对ST受体具有亲和力的肽螯合物，其中螯合物是四齿酸盐。 本发明的肽 - 螯合物缀合物可用放射性金属标记以提供金属络合物。 提供了包含金属络合物的放射性药物组合物，其适用于结肠直肠癌的诊断成像。 本发明还提供了用于制备放射性药物制剂的试剂盒。

公开(公告)号：US20060292075A1

公开(公告)日：2006-12-28

申请号：US11410177

申请日：2006-04-24

申请人： Anthony Storey ,  Marivi Mendizabal ,  Susan Champion ,  Alex Gibson ,  Benedicte Guilbert ,  Ian Wilson ,  Peter Knox

发明人： Anthony Storey ,  Marivi Mendizabal ,  Susan Champion ,  Alex Gibson ,  Benedicte Guilbert ,  Ian Wilson ,  Peter Knox

IPC分类号： A61K51/00 ,  A61K38/12 ,  A61K38/08 ,  C07K7/64 ,  C07K7/08

CPC分类号： A61K49/14 ,  A61K51/088

摘要： Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.

公开(公告)号：US20050063902A1

公开(公告)日：2005-03-24

申请号：US10296952

申请日：2001-06-18

申请人： Anthony Storey ,  Georg Brauers ,  Koichi Hanaoka ,  Yoshihito Minosako ,  Koichi Homma ,  Yoshifumi Shirakami

发明人： Anthony Storey ,  Georg Brauers ,  Koichi Hanaoka ,  Yoshihito Minosako ,  Koichi Homma ,  Yoshifumi Shirakami

IPC分类号： A61K47/02 ,  A61K47/16 ,  A61K47/18 ,  A61K47/22 ,  A61K47/24 ,  A61K51/00 ,  A61K51/04 ,  A61P43/00 ,  A61K31/66

CPC分类号： A61K51/0489

摘要： The present invention provides an improved stabiliser for radiopharmaceuticals which inhibits impurities from being produced by two kinds of decomposition mechanisms and exhibits such an effect that the shelf life of a radiopharmaceutical after its preparation is prolonged as compared with conventional ones. The improvement comprises a combination of an amino-substituted aromatic carboxylic acid or its salt, ester or amide in combination with a diphosphonic acid or its salt.

摘要翻译： 本发明提供一种用于放射性药物的改进的稳定剂，其通过两种分解机制抑制杂质的产生，并且表现出与常规放射性药物相比，其制备后放射性药物的保质期延长的效果。 改进包括氨基取代的芳族羧酸或其盐，酯或酰胺与二膦酸或其盐的组合。

公开(公告)号：US5695290A

公开(公告)日：1997-12-09

申请号：US667162

申请日：1996-06-20

申请人： Stephen M. Mondak ,  John A. Butine ,  Anthony Storey

发明人： Stephen M. Mondak ,  John A. Butine ,  Anthony Storey

IPC分类号： F16C23/08 ,  F16C33/78 ,  F16J15/32

CPC分类号： F16C33/7859 ,  F16C23/086 ,  F16C33/7806 ,  F16J15/3264

摘要： A spherical roller bearing has a seal at each axial end of the inner ring-outer ring annulus. Each seal has two spaced apart metal parts. Elastomeric seal lips are bonded to one metal part and extend into wiping contact with the other metal part. The spherical roller bearings described have three seal lips. In one embodiment two seal lips are bonded to one metal part and one seal lip is bonded to the other metal part. In the other embodiment the three seal lips are bonded to one metal part.

摘要翻译： 一个调心滚子轴承在内环 - 外圈环的每个轴向端都有密封。 每个密封件有两个间隔开的金属部件。 弹性密封唇缘结合到一个金属部分并延伸到与另一个金属部分擦拭接触。 所述的调心滚子轴承有三个密封唇。 在一个实施例中，两个密封唇缘结合到一个金属部分，一个密封唇缘结合到另一个金属部分。 在另一个实施例中，三个密封唇缘结合到一个金属部件。