发明授权
- 专利标题: Amide compounds useful in therapy
- 专利标题(中): 酰胺化合物可用于治疗
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申请号: US12561398申请日: 2009-09-17
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公开(公告)号: US08232269B2公开(公告)日: 2012-07-31
- 发明人: Karl Richard Gibson , Martin Peter Green , Toby James Underwood , Florian Wakenhut
- 申请人: Karl Richard Gibson , Martin Peter Green , Toby James Underwood , Florian Wakenhut
- 申请人地址: US NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: US NY New York
- 代理商 Richard V. Zanzalari
- 主分类号: A61K31/397
- IPC分类号: A61K31/397 ; A61K31/415 ; A61K31/506 ; A61K31/4184 ; A61K31/454 ; C07D231/20 ; C07D205/04 ; C07D403/12 ; C07D235/02 ; C07D401/12
摘要:
A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein, R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy; R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from Ra) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C1-4 alkyl); R4 represents H or C1-3 alkyl; R5 represents C1-6 alkyl (optionally substituted by one or more substituents each independently selected from Rb), C3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het2 (optionally substituted by one or more substituents each independently selected from Rd); oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C1-4 alkyl); and R6 represents C1-3 alkyl (optionally substituted by one or more substituents each independently selected from Rf), C3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen; where Rf represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids.
公开/授权文献
- US20100249091A1 Amide Compounds Useful in Therapy 公开/授权日:2010-09-30
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