发明授权
- 专利标题： Cyclopamine analogues and methods of use thereof
- 专利标题（中）： 环戊胺类似物及其使用方法
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申请号： US12969024申请日： 2010-12-15
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公开(公告)号： US08236956B2公开(公告)日： 2012-08-07
- 发明人: Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
- 申请人： Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
- 申请人地址： US MA Cambridge
- 专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Fish & Richardson P.C.
- 主分类号： C07D491/048
- IPC分类号： C07D491/048 ; C07D491/04
摘要：
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
公开/授权文献
- US20110166353A1 Cyclopamine Analogues and Methods of Use Thereof 公开/授权日：2011-07-07
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