Methods and devices are provided to allow for easy manipulation of a configuration and/or an orientation of seal elements of a surgical access device by an end user. In one exemplary embodiment a surgical access device is provided that includes a retractor configured to be positioned within a surgical incision to provide access to a body cavity, seal elements disposed within a lumen of the retractor, and adjustment mechanisms in communication with the seal elements and which are configured to manipulate an orientation of one or more of the seal elements. Types of adjustment mechanisms capable of manipulating the seal elements as desired include inflatable bladders and electroactive polymers. Exemplary methods for providing easy manipulation of the configuration and/or orientation of seal elements of a surgical access device on location are also provided.