Invention Grant
- Patent Title: 1,3-dihydro-5-isobenzofurancarbonitrile derivatives and pharmaceutical composition thereof for the treatment of premature ejaculation
- Patent Title (中): 1,3-二氢-5-异苯并呋喃腈衍生物及其药物组合物，用于治疗早泄
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Application No.: US12739870Application Date: 2008-10-31
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Publication No.: US08242159B2Publication Date: 2012-08-14
- Inventor: Yeong Geon Lee , Soo-Jung Choi , Tae-Kyung Kang , Mi-Jeong Seo , Chang-Yong Shin , Kyung-Seok Lee , Gook-Jun Ahn , Seul-Min Choi , Yong-Duck Kim , Dong-Hwan Kim , Kyung-Koo Kang , Hyun-Joo Shim , Dong-Sung Kim , Byoung-Ok Ahn , Moo-Hi Yoo
- Applicant: Yeong Geon Lee , Soo-Jung Choi , Tae-Kyung Kang , Mi-Jeong Seo , Chang-Yong Shin , Kyung-Seok Lee , Gook-Jun Ahn , Seul-Min Choi , Yong-Duck Kim , Dong-Hwan Kim , Kyung-Koo Kang , Hyun-Joo Shim , Dong-Sung Kim , Byoung-Ok Ahn , Moo-Hi Yoo
- Applicant Address: KR Seoul
- Assignee: Dong-A Pharmaceutical. Co., Ltd
- Current Assignee: Dong-A Pharmaceutical. Co., Ltd
- Current Assignee Address: KR Seoul
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2007-0111783 20071102; KR10-2008-0105439 20081027
- International Application: PCT/KR2008/006445 WO 20081031
- International Announcement: WO2009/057974 WO 20090507
- Main IPC: A61K31/415
- IPC: A61K31/415 ; A61K31/4164 ; A61K31/38 ; A61K31/34 ; C07D233/00 ; C07D231/00 ; C07D409/00 ; C07D307/02
Abstract:
Disclosed herein are novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives represented by Formula 1, or pharmaceutically acceptable salts thereof. Also disclosed is a pharmaceutical composition for treating or preventing premature ejaculation including the compound. The 1,3-dihydro-5-isobenzofurancarbonitrile derivatives have a short half-life and inhibit the ejaculation process by selectively inhibiting serotonin reuptake via a serotonin reuptake transporter present in a presynaptic neuron. Thus, the compounds are useful in the treatment and prevention of premature ejaculation.
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