发明授权
US08242244B2 Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
有权
在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质
- 专利标题: Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
- 专利标题(中): 在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质
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申请号: US12798979申请日: 2010-04-14
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公开(公告)号: US08242244B2公开(公告)日: 2012-08-14
- 发明人: Zhiwen Zhang , Lital Alfonta , Peter Schultz
- 申请人: Zhiwen Zhang , Lital Alfonta , Peter Schultz
- 申请人地址: US CA La Jolla
- 专利权人: The Scripps Research Institute
- 当前专利权人: The Scripps Research Institute
- 当前专利权人地址: US CA La Jolla
- 代理机构: Quine Intellectual Property Law Group, P.C.
- 代理商 Gary Baker
- 主分类号: C07K14/00
- IPC分类号: C07K14/00 ; C12N9/00 ; C12N15/74 ; C07H21/02
摘要:
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
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