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1.发明申请Selective Incorporation of 5-hydroxytryptophan into Proteins in Mammalian Cells 有权选择性将5-羟色氨酸并入哺乳动物细胞中的蛋白质公开(公告)号：US20120282626A1
公开(公告)日：2012-11-08
申请号：US13546582
申请日：2012-07-11
申请人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
摘要翻译： 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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2.发明授权Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells 有权在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质公开(公告)号：US08242244B2
公开(公告)日：2012-08-14
申请号：US12798979
申请日：2010-04-14
申请人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
摘要翻译： 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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公开(公告)号：US07709604B2
公开(公告)日：2010-05-04
申请号：US11016348
申请日：2004-12-16
申请人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
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4.发明申请公开(公告)号：US20070009990A1
公开(公告)日：2007-01-11
申请号：US10575991
申请日：2004-10-13
申请人： Lital Alfonta , Peter Schultz , Zhiwen Zhang
发明人： Lital Alfonta , Peter Schultz , Zhiwen Zhang
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
摘要翻译： 提供了将氧化还原活性氨基酸掺入蛋白质的蛋白质生物合成机理组分的组成和方法，其中包括正交tRNA，正交氨酰-tRNA合成酶和tRNA /合成酶正交对。 还提供了用于鉴定这些正交对的方法以及使用这些正交对产生具有氧化还原活性氨基酸的蛋白质的方法。
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5.发明申请Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells 有权在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质公开(公告)号：US20110124080A1
公开(公告)日：2011-05-26
申请号：US12798979
申请日：2010-04-14
申请人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
IPC分类号： C12N9/00
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
摘要翻译： 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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6.发明申请Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells 有权在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质公开(公告)号：US20070111193A1
公开(公告)日：2007-05-17
申请号：US10580987
申请日：2004-12-16
申请人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
摘要翻译： 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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7.发明申请公开(公告)号：US20050227318A1
公开(公告)日：2005-10-13
申请号：US10965218
申请日：2004-10-13
申请人： Lital Alfonta , Peter Schultz , Zhiwen Zhang
发明人： Lital Alfonta , Peter Schultz , Zhiwen Zhang
IPC分类号： C07H21/04 , C12N20060101 , C12N1/21 , C12N9/00 , C12N9/10 , C12N15/74 , C12P21/02 , C12P21/06
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
摘要翻译： 提供了将氧化还原活性氨基酸掺入蛋白质的蛋白质生物合成机理组分的组成和方法，其中包括正交tRNA，正交氨基-tRNA合成酶和tRNA /合成酶正交对。 还提供了用于鉴定这些正交对的方法以及使用这些正交对产生具有氧化还原活性氨基酸的蛋白质的方法。
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8.发明授权Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells 有权在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质公开(公告)号：US07741071B2
公开(公告)日：2010-06-22
申请号：US10580987
申请日：2004-12-16
申请人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
摘要翻译： 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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9.发明申请Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells 有权在哺乳动物细胞中将5-羟色氨酸选择性掺入蛋白质公开(公告)号：US20050136513A1
公开(公告)日：2005-06-23
申请号：US11016348
申请日：2004-12-16
申请人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
发明人： Zhiwen Zhang , Lital Alfonta , Peter Schultz
摘要： This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
摘要翻译： 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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公开(公告)号：US09783798B2
公开(公告)日：2017-10-10
申请号：US13344436
申请日：2012-01-05
申请人： Lital Alfonta , Peter G. Schultz , Zhiwen Zhang
发明人： Lital Alfonta , Peter G. Schultz , Zhiwen Zhang
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
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