发明授权
- 专利标题： Method of inducing memory B cell development and terminal differentiation
- 专利标题（中）： 诱导记忆B细胞发育和终末分化的方法
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申请号： US12126166申请日： 2008-05-23
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公开(公告)号： US08247228B2公开(公告)日： 2012-08-21
- 发明人: Catherine Rachel Ettinger , Peter E. Lipsky , Warren J. Leonard , Rosanne Spolski , Herbert C. Morse, III
- 申请人： Catherine Rachel Ettinger , Peter E. Lipsky , Warren J. Leonard , Rosanne Spolski , Herbert C. Morse, III
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Leydig, Voit & Mayer
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12N5/07
摘要：
The invention provides a method for promoting differentiation of a mature naïve B cell or a B cell progenitor into a memory B cell or a plasma cell. The method comprises (a) contacting a population of cells comprising a mature naïve B cell or a B cell progenitor with an agent that activates at least one of JAK1, JAK3, STAT3, STAT5A or STAT5B; wherein the population of cells optionally is contacted with an antigen, and (b) isolating the memory B cell or plasma cell.
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