发明授权
- 专利标题： Deuterated hepatitis C protease inhibitors
- 专利标题（中）： 氘代丙型肝炎蛋白酶抑制剂
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申请号： US12953876申请日： 2010-11-24
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公开(公告)号： US08247532B2公开(公告)日： 2012-08-21
- 发明人: Robert B. Perni , Youssef Bennani , Gregor Zlokarnik , Gerald J. Tanoury , Minzhang Chen , Young Chun Jung , Raymond E. Forslund , Francois Maltais
- 申请人： Robert B. Perni , Youssef Bennani , Gregor Zlokarnik , Gerald J. Tanoury , Minzhang Chen , Young Chun Jung , Raymond E. Forslund , Francois Maltais
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理机构： Honigman Miller Schwartz and Cohn
- 代理商 Kathryn D. Soulier; Jonathan P. O'Brien
- 主分类号： A61K38/04
- IPC分类号： A61K38/04
摘要：
This invention relates to processes and intermediates for the preparation of salts of deuterated, enantiomericallv enriched alpha-amino beta-hydroxy acids of Formula 1 wherein the variables R1,R′1 and R′2 are defined herein, and wherein the process may comprise the steps of forming a salt of a compound of Formula 1, and crystallizing said salt to give a compound of greater than 55% enantiomeric excess.
公开/授权文献
- US20110071074A1 DEUTERATED HEPATITIS C PROTEASE INHIBITORS 公开/授权日：2011-03-24
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