发明授权
- 专利标题： Crystalline solvate of omeprazole sodium
- 专利标题（中）： 奥美拉唑钠的结晶溶剂化物
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申请号： US11916462申请日： 2006-06-07
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公开(公告)号： US08247566B2公开(公告)日： 2012-08-21
- 发明人: Lidija Vranicar Savanovic , Zoran Ham , Janez Rzen
- 申请人： Lidija Vranicar Savanovic , Zoran Ham , Janez Rzen
- 申请人地址： SI Ljubljana
- 专利权人： Lek Pharmaceuticals d.d.
- 当前专利权人： Lek Pharmaceuticals d.d.
- 当前专利权人地址： SI Ljubljana
- 代理机构： Luedeka Neely Group, P.C.
- 优先权： SI200500172 20050608
- 国际申请： PCT/EP2006/005425 WO 20060607
- 国际公布： WO2006/131338 WO 20061214
- 主分类号： C07D401/12
- IPC分类号： C07D401/12
摘要：
The present invention belongs to the field of pharmaceutical industry and relates to novel crystalline omeprazole sodium ethanol solvate and to the process for its preparation, which acts as intermediary compound to the processes for its conversion into different crystalline forms, first of all to a known omeprazole sodium form A, with low amount of residual solvents, i.e. less than 0.5% by weight of residual solvent.The present invention also relates to novel crystalline omeprazole sodium form E and crystalline omeprazole sodium form F as well to the processes for their preparation as well, both with considerably low levels of residual solvents.Omeprazole sodium form A and both novel crystalline forms omeprazole sodium form E and form F are useful for the treatment of gastrointestinal disorders.
公开/授权文献
- US20090221646A1 CRYSTALLINE SOLVATE OF OMEPRAZOLE SODIUM 公开/授权日：2009-09-03
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