发明授权
- 专利标题： Dry powder pharmaceutical compositions comprising surfactants, hydrophobic active principles, and water-soluble excipients, process of preparing, and stable aqueous suspensions thereof
- 专利标题（中）： 包含表面活性剂，疏水性活性成分和水溶性赋形剂的干粉药物组合物，制备方法及其稳定的水性悬浮液
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申请号： US11578661申请日： 2005-04-21
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公开(公告)号： US08252334B2公开(公告)日： 2012-08-28
- 发明人: Giovanni Caponetti , Mariella Artusi , Loretta Maggi , Paolo Corvi Mora
- 申请人： Giovanni Caponetti , Mariella Artusi , Loretta Maggi , Paolo Corvi Mora
- 申请人地址： IT Milan
- 专利权人： Eratech S.r.l.
- 当前专利权人： Eratech S.r.l.
- 当前专利权人地址： IT Milan
- 代理机构： Jacobson Holman PLLC
- 优先权： ITMI04A0795 20040423
- 国际申请： PCT/EP2005/004277 WO 20050421
- 国际公布： WO2005/102283 WO 20051103
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/10 ; A61K9/14
摘要：
Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
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