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1.发明申请Dry Powder Pharmaceutical Composition, Its Preparation Process and Stable Aqueous Suspension Obtained from Such Composition 有权干粉药物组合物，其制备方法和由这种组合物获得的稳定的水悬浮液公开(公告)号：US20070224276A1
公开(公告)日：2007-09-27
申请号：US11578661
申请日：2005-04-21
IPC分类号： A61K9/16
CPC分类号： A61K9/145 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/143 , A61K31/192 , A61K31/573 , A61K31/58
摘要： Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
摘要翻译： 包含至少一种疏水活性成分，至少一种水溶性赋形剂和至少一种表面活性剂的干粉形式的药物组合物，其中所述干燥粉末状态的颗粒具有体积平均直径VMD < 大于在水介质中在标准条件下从所述药物组合物获得的悬浮液中的颗粒的体积平均直径VMD 。 还公开了制备这种干组合物和可从所述干组合物获得的用于吸入治疗的临时悬浮液的方法。
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2.发明授权Dry powder pharmaceutical compositions comprising surfactants, hydrophobic active principles, and water-soluble excipients, process of preparing, and stable aqueous suspensions thereof 有权包含表面活性剂，疏水性活性成分和水溶性赋形剂的干粉药物组合物，制备方法及其稳定的水性悬浮液公开(公告)号：US08252334B2
公开(公告)日：2012-08-28
申请号：US11578661
申请日：2005-04-21
CPC分类号： A61K9/145 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/143 , A61K31/192 , A61K31/573 , A61K31/58
摘要： Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
摘要翻译： 包含至少一种疏水活性成分，至少一种水溶性赋形剂和至少一种表面活性剂的干粉形式的药物组合物，其中所述干粉状态的颗粒的体积平均直径VMDd大于体积平均直径VMDd， 在由水介质中分散的标准条件下由所述药物组合物获得的悬浮液中的颗粒。 还公开了制备这种干组合物和可从所述干组合物获得的用于吸入治疗的临时悬浮液的方法。
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3.发明申请Dry Powder Pharmaceutical Compositions, Its Preparation Process and Stable Aqueous Suspension Obtained from such Composition 审中-公开干粉药物组合物，其制备方法和从该组合物获得的稳定的水悬浮液公开(公告)号：US20130052233A1
公开(公告)日：2013-02-28
申请号：US13558566
申请日：2012-07-26
CPC分类号： A61K9/145 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/143 , A61K31/192 , A61K31/573 , A61K31/58
摘要： Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
摘要翻译： 包含至少一种疏水活性成分，至少一种水溶性赋形剂和至少一种表面活性剂的干粉形式的药物组合物，其中所述干粉状态的颗粒的体积平均直径VMDd大于体积平均直径VMDd， 在由水介质中分散的标准条件下由所述药物组合物获得的悬浮液中的颗粒。 还公开了制备这种干组合物和可从所述干组合物获得的用于吸入治疗的临时悬浮液的方法。
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公开(公告)号：US20050019411A1
公开(公告)日：2005-01-27
申请号：US10492816
申请日：2002-10-17
申请人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Pier Luigi Catellani , Mariella Artusi , Cecilia Sacchetti
发明人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Pier Luigi Catellani , Mariella Artusi , Cecilia Sacchetti
CPC分类号： A61K9/0043 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652
摘要： The present invention concerns drug formulae for nasal administration and insufflators filled with said formula. The present invention also concerns methods for making said formulae available as well as primary particles for obtaining chimerical agglomerates that can be used in said formulae.
摘要翻译： 本发明涉及用于鼻腔给药的药物配方和填充有所述配方的吹入器。 本发明还涉及使所述配方可用的方法以及用于获得可用于所述配方中的嵌合共聚物的初级颗粒。
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