A method and apparatus for serving high speed downlink shared channel (HS-DSCH) cell change are disclosed. A wireless transmit/receive unit (WTRU) sends a measurement report to a radio network controller (RNC) when a signal strength of a target cell approaches a signal strength of a source cell. The RNC adds the target cell in an active set and sends pre-loaded HS-DSCH configuration information for the target cell to the WTRU. The WTRU sends another measurement report when a signal strength of the target cell exceeds that of the source cell. The WTRU monitors a high speed shared control channel (HS-SCCH) on the target cell based on the pre-loaded HS-DSCH configuration information and decodes an HS-SCCH transmission. The WTRU determines whether a MAC-hs/ehs reset is required and if so resets a MAC-hs/ehs entity prior to receiving an HS-DSCH transmission from the target cell.