发明授权
- 专利标题： Inhibitors of protein kinases
- 专利标题（中）： 蛋白激酶抑制剂
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申请号： US12386848申请日： 2009-04-22
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公开(公告)号： US08258144B2公开(公告)日： 2012-09-04
- 发明人: Yonghong Song , Qing Xu , Shawn M. Bauer , Zhaozhong J. Jia , Mukund Mehrotra , Anjali Pandey
- 申请人： Yonghong Song , Qing Xu , Shawn M. Bauer , Zhaozhong J. Jia , Mukund Mehrotra , Anjali Pandey
- 申请人地址： US CA South San Francisco
- 专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 主分类号： C07D487/00
- IPC分类号： C07D487/00 ; A61K31/519
摘要：
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
公开/授权文献
- US20090298823A1 Inhibitors of protein kinases 公开/授权日：2009-12-03
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