Invention Grant
- Patent Title: Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer
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Application No.: US12079900Application Date: 2008-03-28
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Publication No.: US08263329B2Publication Date: 2012-09-11
- Inventor: Susanne M. Gollin , Rahul Atul Parikh , Xin Huang
- Applicant: Susanne M. Gollin , Rahul Atul Parikh , Xin Huang
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh - Of The Commonwealth System Of Higher Education
- Current Assignee: University of Pittsburgh - Of The Commonwealth System Of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Baker Botts L.L.P.
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation which could be overcome by inhibition of the ATR/CHEK1 pathway. It provides for methods of identifying patients unlikely to exhibit an adequate response to radiation therapy and/or chemotherapy who may benefit from ATR/CHEK1 pathway inhibition, as well as methods of treating said patients.
Public/Granted literature
- US20100324112A1 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer Public/Granted day:2010-12-23
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