发明授权
US08268820B2 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
失效
2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟丙基化合物
- 专利标题： 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
- 专利标题（中）： 2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟丙基化合物
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申请号： US12727271申请日： 2010-03-19
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公开(公告)号： US08268820B2公开(公告)日： 2012-09-18
- 发明人: Daniel Hunziker , Chrisitan Lerner , Werner Mueller , Ulrike Obst Sander , Philippe Pflieger , Pius Waldmeier
- 申请人： Daniel Hunziker , Chrisitan Lerner , Werner Mueller , Ulrike Obst Sander , Philippe Pflieger , Pius Waldmeier
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Gene J. Yao
- 优先权： EP09156267 20090326
- 主分类号： C07D265/36
- IPC分类号： C07D265/36 ; A61K31/536
摘要：
The present invention relates to compounds of formula I wherein R1a to R1c, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
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