Invention Grant
US08268820B2 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
失效
2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟丙基化合物
- Patent Title: 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
- Patent Title (中): 2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟丙基化合物
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Application No.: US12727271Application Date: 2010-03-19
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Publication No.: US08268820B2Publication Date: 2012-09-18
- Inventor: Daniel Hunziker , Chrisitan Lerner , Werner Mueller , Ulrike Obst Sander , Philippe Pflieger , Pius Waldmeier
- Applicant: Daniel Hunziker , Chrisitan Lerner , Werner Mueller , Ulrike Obst Sander , Philippe Pflieger , Pius Waldmeier
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Gene J. Yao
- Priority: EP09156267 20090326
- Main IPC: C07D265/36
- IPC: C07D265/36 ; A61K31/536
Abstract:
The present invention relates to compounds of formula I wherein R1a to R1c, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
Public/Granted literature
- US20100249124A1 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS Public/Granted day:2010-09-30
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