Invention Grant
- Patent Title: Substituted pyrimidines useful as protein kinase inhibitors
- Patent Title (中): 可用作蛋白激酶抑制剂的取代嘧啶
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Application No.: US12436407Application Date: 2009-05-06
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Publication No.: US08268829B2Publication Date: 2012-09-18
- Inventor: Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
- Applicant: Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Inc.
- Current Assignee: Vertex Pharmaceuticals Inc.
- Current Assignee Address: US MA Cambridge
- Agent Rory C. Stewart
- Main IPC: C07D403/14
- IPC: C07D403/14 ; A61K31/4155
Abstract:
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
Public/Granted literature
- US20090221602A1 PROCESSES FOR PREPARING SUBSTITUTED PYRIMIDINES Public/Granted day:2009-09-03
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