发明授权
US08283364B2 Compounds which have activity at M1 receptor and their uses in medicine
有权
具有M1受体活性的化合物及其在药物中的用途
- 专利标题: Compounds which have activity at M1 receptor and their uses in medicine
- 专利标题(中): 具有M1受体活性的化合物及其在药物中的用途
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申请号: US12088465申请日: 2006-09-27
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公开(公告)号: US08283364B2公开(公告)日: 2012-10-09
- 发明人: Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
- 申请人: Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
- 申请人地址: GB Greenford, Middlesex
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB Greenford, Middlesex
- 代理商 Linda E. Hall; John L. Lemanowicz
- 优先权: GB0519950.0 20050930; GB0602040.8 20060201
- 国际申请: PCT/GB2006/003590 WO 20060927
- 国际公布: WO2007/036715 WO 20070405
- 主分类号: A61K31/454
- IPC分类号: A61K31/454 ; C07D405/04
摘要:
Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
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