发明授权
US08288560B2 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
有权
具有5个成员的杂环衍生物，其制备及其作为药物的用途
- 专利标题： Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
- 专利标题（中）： 具有5个成员的杂环衍生物，其制备及其作为药物的用途
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申请号： US13053092申请日： 2011-03-21
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公开(公告)号： US08288560B2公开(公告)日： 2012-10-16
- 发明人: Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
- 申请人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
- 申请人地址： FR Boulogne Billancourt
- 专利权人： Ipsen Pharma S.A.S.
- 当前专利权人： Ipsen Pharma S.A.S.
- 当前专利权人地址： FR Boulogne Billancourt
- 代理机构： Hunton & Williams LLP
- 优先权： FR99/12643 19991011; FR00/10151 20000801; FR00/11169 20000901; FR01/04943 20010410; FR02/01811 20020214
- 主分类号： C07D277/28
- IPC分类号： C07D277/28
摘要：
The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
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