Invention Grant
- Patent Title: Process for preparing α-keto acids and derivatives thereof
- Patent Title (中): 制备α-酮酸及其衍生物的方法
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Application No.: US12169683Application Date: 2008-07-09
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Publication No.: US08299293B2Publication Date: 2012-10-30
- Inventor: Christoph Kobler , Martin Hateley , Philipp Roth , Barbara Jaeger , Christoph Weckbecker , Klaus Huthmacher
- Applicant: Christoph Kobler , Martin Hateley , Philipp Roth , Barbara Jaeger , Christoph Weckbecker , Klaus Huthmacher
- Applicant Address: DE Essen
- Assignee: Evonik Degussa GmbH
- Current Assignee: Evonik Degussa GmbH
- Current Assignee Address: DE Essen
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: DE102007031917 20070709
- Main IPC: C07C323/22
- IPC: C07C323/22 ; C07C69/66 ; C07C67/36 ; C07C69/73 ; C07C59/00

Abstract:
A method for preparing α-keto acids, especially α-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting α,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the α-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.
Public/Granted literature
- US20090076302A1 PROCESS FOR PREPARING a-KETO ACIDS AND DERIVATIVES THEREOF Public/Granted day:2009-03-19
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