A method for deriving precise control over laser power of an optical pickup unit (OPU) includes: providing an analog-to-digital converter (ADC) within an automatic power calibration (APC) circuit to derive a path gain and/or a path offset from the APC circuit; and selectively performing compensation according to the gain and/or the path offset, in order to maintain precision of a relationship between the laser power and a target command utilized for controlling the laser power. An associated APC circuit comprising an ADC and at least one compensation module is further provided. The ADC is utilized for deriving a path gain and/or a path offset from the APC circuit. The compensation module is utilized for selectively performing compensation according to the path gain and/or the path offset, in order to control the laser power by a target command.