发明授权
- 专利标题： Method for the secretory production of heterologous protein in Escherichia coli
- 专利标题（中）： 在大肠杆菌中分泌异源蛋白质的方法
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申请号： US12919198申请日： 2009-02-06
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公开(公告)号： US08304210B2公开(公告)日： 2012-11-06
- 发明人: Cheol-Ho Pan , Joo Young Lee , Byung Hun Um , Sang Moo Kim , Dae-Geun Song
- 申请人： Cheol-Ho Pan , Joo Young Lee , Byung Hun Um , Sang Moo Kim , Dae-Geun Song
- 申请人地址： KR Seoul
- 专利权人： Korea Institute of Science and Technology
- 当前专利权人： Korea Institute of Science and Technology
- 当前专利权人地址： KR Seoul
- 代理机构： Lowe Hauptman Ham & Berner, LLP
- 优先权： KR10-2009-0006094 20090123
- 国际申请： PCT/KR2009/000583 WO 20090206
- 国际公布： WO2010/085012 WO 20100729
- 主分类号： C12P21/06
- IPC分类号： C12P21/06
摘要：
The present invention relates to a signal sequence peptide for the improvement of extracellular secretion efficiency of a heterologous protein in E. coli. More particularly, the present invention relates to a gene construct for the improvement of extracellular secretion efficiency of the said heterologous protein in E. coli, which comprises a polynucleotide encoding a recombinant protein composed of the heterologous protein linked to C-terminal of the signal sequence peptide represented by SEQ. ID. NO. 3. The present invention contributes to the improvement of extracellular secretion efficiency of a recombinant protein, so that it can be effectively applied to the production of a recombinant protein.
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