发明授权
- 专利标题： Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage
- 专利标题（中）： 使用季铵吡啶盐作为抗电离辐射诱发的损伤的治疗或预防剂
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申请号： US12287664申请日： 2008-10-09
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公开(公告)号： US08304439B1公开(公告)日： 2012-11-06
- 发明人: Jerzy Gebicki , Andrzej Marcinek , Stefan Chlopicki , Marek K. Janiak
- 申请人： Jerzy Gebicki , Andrzej Marcinek , Stefan Chlopicki , Marek K. Janiak
- 申请人地址： PL Lodz PL Krakow
- 专利权人： Politechnika Lodzka,Uniwersylet Jagiellonski
- 当前专利权人： Politechnika Lodzka,Uniwersylet Jagiellonski
- 当前专利权人地址： PL Lodz PL Krakow
- 代理机构： Cooper & Dunham LLP
- 代理商 Gary J. Gershik
- 主分类号： A61K31/44
- IPC分类号： A61K31/44
摘要：
A method for the treatment or prevention of a cell or tissue damage in a living subject due to the exposure to ionizing radiation is provided, which comprises administration to said subject of a compound of formula (I) wherein R′ is H, OH, CONH2 or COCH3, R″ is H or CH3, R′″ is H or CH3, and X− is a pharmaceutically acceptable counterion, in an amount sufficient to inhibit radiation-induced damage.
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