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1.发明授权Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage 有权使用季铵吡啶盐作为抗电离辐射诱发的损伤的治疗或预防剂公开(公告)号：US08304439B1
公开(公告)日：2012-11-06
申请号：US12287664
申请日：2008-10-09
IPC分类号： A61K31/44
CPC分类号： A61K31/4425
摘要： A method for the treatment or prevention of a cell or tissue damage in a living subject due to the exposure to ionizing radiation is provided, which comprises administration to said subject of a compound of formula (I) wherein R′ is H, OH, CONH2 or COCH3, R″ is H or CH3, R′″ is H or CH3, and X− is a pharmaceutically acceptable counterion, in an amount sufficient to inhibit radiation-induced damage.
摘要翻译： 提供了一种用于治疗或预防由暴露于电离辐射引起的活体受试者中的细胞或组织损伤的方法，其包括向所述受试者施用式（I）化合物，其中R'为H，OH，CONH 2 或COCH 3，R“是H或CH 3，R”“是H或CH 3，X-是药学上可接受的抗衡离子，其量足以抑制辐射诱发的损伤。
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2.发明申请METHOD FOR INHIBITING AND/OR PREVENTING FORMATION OF CANCER METASTASES AND SECONDARY MALIGNANT CANCER 审中-公开用于抑制和/或预防癌症癌症和次要恶性肿瘤的形成的方法公开(公告)号：US20110201653A1
公开(公告)日：2011-08-18
申请号：US13094575
申请日：2011-04-26
IPC分类号： A61K31/44 , A61K31/4425 , A61P35/00
CPC分类号： A61K31/4425
摘要： The invention relates to a method for inhibiting and/or preventing formation of cancer metastases and secondary malignant cancers by administration to a subject of an effective amount of a quaternary pyridinium salt of formula I wherein R′ is selected from the group consisting of H, OH, CONH2, COCH3, R″ is selected from the group consisting of H, CH3, R′″ represents H or CH3, and X− is a pharmaceutically acceptable counterion.
摘要翻译： 本发明涉及一种通过向受试者施用有效量的式I的季吡啶鎓盐来抑制和/或预防癌症转移和继发性恶性肿瘤形成的方法，其中R'选自H，OH ，CONH 2，COCH 3，R“选自H，CH 3，R'”表示H或CH 3，X-是药学上可接受的抗衡离子。
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3.发明申请Use of Quaternary Pyridinium Compounds for Vasoprotection and/or Hepatoprotection 有权使用第四纪吡啶鎓化合物进行血管保护和/或肝保护公开(公告)号：US20080221172A1
公开(公告)日：2008-09-11
申请号：US12038381
申请日：2008-02-27
申请人： Andrzej MARCINEK , Stefan Chlopicki , Jerzy Gebicki , Jan Adamus
发明人： Andrzej MARCINEK , Stefan Chlopicki , Jerzy Gebicki , Jan Adamus
IPC分类号： A61K31/4406 , A61K31/4402 , A61P9/00 , A61P3/00 , A61P19/00 , A61P1/00 , A61P15/00 , A61P29/00 , A61P25/00 , A61K31/4409
CPC分类号： A61K31/4425 , A61K31/444
摘要： The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of: wherein R represents hydrogen atom, CH3, OH, pyridyl (C5H4N), 1-methylpyridyl (C5H4N—CH3) or pyridyl substituted with hydroxy group ((OH)C5H3N), and X represents a physiologically acceptable counterion.
摘要翻译： 本发明涉及用于治疗或预防与血管内皮功能障碍或肝损伤相关的疾病或病症的方法，其包括向患者施用需要这种治疗或预防治疗或预防有效量的选自 由下式组成：其中R表示氢原子，CH 3，OH，吡啶基（C 5 H 4 N N），1-甲基吡啶基（C 或者被羟基（（OH）C 5 H 5）取代的吡啶基，或者被羟基取代的吡啶基（（OH）C 5 H 5） SUB> 3N），X表示生理上可接受的抗衡离子。
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4.发明申请公开(公告)号：US20120310057A1
公开(公告)日：2012-12-06
申请号：US13483625
申请日：2012-05-30
IPC分类号： A61B5/1455
CPC分类号： A61B5/0071 , A61B5/02007 , A61B5/14546 , A61B5/441 , A61B5/7271
摘要： A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal emitted from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.
摘要翻译： 用于评价人受试者的血管内皮功能的方法包括监测作为时间的函数从所述受试者的上肢的皮肤组织细胞发射的NADH荧光信号的强度变化，其中所述变化来自由阻断和释放引起的反应性高血钾 所述受试者的上肢的血液流动。 用于评估人类受试者的血管内皮功能的系统包括用激发光照亮所述受试者的上肢皮肤的装置，用于测量从皮肤发出的荧光信号的强度并记录所述荧光强度的变化的装置 信号随着时间推移; 以及用于阻断和释放所述受试者的上肢中的血液流动的限制装置。
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5.发明申请公开(公告)号：US20110082177A1
公开(公告)日：2011-04-07
申请号：US12997500
申请日：2009-06-26
IPC分类号： A61K31/455 , C07D213/82 , A61P9/00 , A61P9/06 , A61P7/02 , A61P9/10 , A61P9/12
CPC分类号： C07D213/82
摘要： The invention relates to the novel N′-nitroxyalkylnicotinamide derivatives represented by the general formula I wherein R1 is C1-C4 alkyl; R2 is hydrogen. C1-C4 alkyl, CH2OH or CH2ONO2; R3 is ONO2, CH2ONO2 or OH; provided that when R3 is OH, R2 is CH2ONO2; and X− is an organic or inorganic anion; as well as pharmaceutical compositions thereof and their use as a medicament, in particular, in the treatment of diseases of the cardiovascular system.
摘要翻译： 本发明涉及由通式Ⅰ表示的新的N'-硝基烷基烟酰胺衍生物，其中R 1是C 1 -C 4烷基; R2是氢。 C1-C4烷基，CH2OH或CH2ONO2; R3是ONO2，CH2ONO2或OH; 条件是当R3为OH时，R2为CH2ONO2; X-是有机或无机阴离子; 以及其药物组合物及其作为药物的用途，特别是用于治疗心血管系统的疾病。
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公开(公告)号：US09155472B2
公开(公告)日：2015-10-13
申请号：US13483625
申请日：2012-05-30
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/145 , A61B5/02
CPC分类号： A61B5/0071 , A61B5/02007 , A61B5/14546 , A61B5/441 , A61B5/7271
摘要： A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal emitted from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.
摘要翻译： 用于评价人受试者的血管内皮功能的方法包括监测作为时间的函数从所述受试者的上肢的皮肤组织细胞发射的NADH荧光信号的强度变化，其中所述变化来自由阻断和释放引起的反应性高血钾 所述受试者的上肢的血液流动。 用于评估人类受试者的血管内皮功能的系统包括用激发光照亮所述受试者的上肢皮肤的装置，用于测量从皮肤发出的荧光信号的强度并记录所述荧光强度的变化的装置 信号随着时间推移; 以及用于阻断和释放所述受试者的上肢中的血液流动的限制装置。
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7.发明申请Use of Quaternary Pyridinium Compounds for Vasoprotection and/or Hepatoprotection 失效使用第四纪吡啶鎓化合物进行血管保护和/或肝保护公开(公告)号：US20110118316A1
公开(公告)日：2011-05-19
申请号：US13011364
申请日：2011-01-21
申请人： Andrzej MARCINEK , Stefan Chlopicki , Jerzy Gebicki , Jan Adamus
发明人： Andrzej MARCINEK , Stefan Chlopicki , Jerzy Gebicki , Jan Adamus
IPC分类号： A61K31/4425 , A61K31/444 , A61P1/16
CPC分类号： A61K31/4425 , A61K31/444
摘要： The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of: wherein R represents hydrogen atom, CH3, OH, pyridyl (C5H4N), 1-methylpyridyl (C5H4N—CH3) or pyridyl substituted with hydroxy group ((OH)C5H3N), and X represents a physiologically acceptable counterion.
摘要翻译： 本发明涉及用于治疗或预防与血管内皮功能障碍或肝损伤相关的疾病或病症的方法，其包括向患者施用需要这种治疗或预防治疗或预防有效量的选自 其中R代表氢原子，CH3，OH，吡啶基（C5H4N），1-甲基吡啶基（C5H4N-CH3）或被羟基（（OH）C5H3N）取代的吡啶基，X代表生理上可接受的抗衡离子。
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8.发明申请Method for inhibiting and/or preventing formation of cancer metastases and seconddary malignant cancers 审中-公开用于抑制和/或预防癌症转移和二次恶性肿瘤形成的方法公开(公告)号：US20090118340A1
公开(公告)日：2009-05-07
申请号：US12287671
申请日：2008-10-09
IPC分类号： A61K31/4425 , A61P35/04
CPC分类号： A61K31/4425
摘要： The invention relates to a method for inhibiting and/or preventing formation of cancer metastases and secondary malignant cancers by administration to a subject of an effective amount of a quaternary pyridinium salt of formula I wherein R′ is selected from the group consisting of H, OH, CONH2, COCH3, R″ is selected from the group consisting of H, CH3, R′″ represents H or CH3, and X− is a pharmaceutically acceptable counterion.
摘要翻译： 本发明涉及一种通过向受试者施用有效量的式I的季吡啶鎓盐来抑制和/或预防癌症转移和继发性恶性肿瘤形成的方法，其中R'选自H，OH ，CONH 2，COCH 3，R“选自H，CH 3，R”'表示H或CH 3，X-是药学上可接受的抗衡离子。
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9.发明授权1-methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities 有权1-甲基烟酰胺衍生物和用于治疗脂蛋白异常的制剂公开(公告)号：US08211922B2
公开(公告)日：2012-07-03
申请号：US12690797
申请日：2010-01-20
申请人： Robert Bender , Stefan Chlopicki , Jerzy Gebicki
发明人： Robert Bender , Stefan Chlopicki , Jerzy Gebicki
CPC分类号： A61K31/505 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/44 , A61K31/455 , A61K31/47 , A61K31/55 , A61K31/60 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to nicotinamide derivatives, and their use in treating lipoprotein abnormalities, alone or in combination with a statin.
摘要翻译： 本发明涉及烟酰胺衍生物及其在治疗脂蛋白异常中的用途，单独或与他汀组合使用。
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10.发明授权Method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia with a 1-methylnicotinamide salt 有权用1-甲基烟酰胺盐治疗高甘油三酯血症，血脂异常和高胆固醇血症的方法公开(公告)号：US07935717B2
公开(公告)日：2011-05-03
申请号：US10585892
申请日：2005-01-07
申请人： Jerzy Gebicki , Stefan Chlopicki
发明人： Jerzy Gebicki , Stefan Chlopicki
IPC分类号： A61K31/4425
CPC分类号： A61K31/455 , A23L33/30 , A61K9/0053 , A61K9/007 , A61K31/4406 , A61K31/4425
摘要： The invention is directed to a method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia by administration of a 1-methylnicotinamide salt.
摘要翻译： 本发明涉及一种通过施用1-甲基烟酰胺盐治疗高甘油三酯血症，血脂异常和高胆固醇血症的方法。
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