发明授权
- 专利标题: Method for producing thiazole compound
- 专利标题(中): 噻唑化合物的制备方法
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申请号: US12087587申请日: 2007-01-11
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公开(公告)号: US08304558B2公开(公告)日: 2012-11-06
- 发明人: Naoyuki Takano , Morio Yamamoto , Shinzo Seko
- 申请人: Naoyuki Takano , Morio Yamamoto , Shinzo Seko
- 申请人地址: JP Tokyo
- 专利权人: Sumitomo Chemical Company, Limited
- 当前专利权人: Sumitomo Chemical Company, Limited
- 当前专利权人地址: JP Tokyo
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: JP2006-005687 20060113
- 国际申请: PCT/JP2007/050193 WO 20070111
- 国际公布: WO2007/080903 WO 20070719
- 主分类号: C07D277/20
- IPC分类号: C07D277/20
摘要:
Disclosed is a simple and advantageous method for producing a thiazole compound, which method is suitable for commercial-scale implementation. In this method, a thiazole compound is produced by a reaction between 2-halogeno-allylisothiocyanate and sulfuryl chloride generating a large amount of heat, while suppressing decrease in the yield of the thiazole compound. Specifically disclosed is a method for producing 2-chloro-5-chloromethylthiazole represented by the formula (1): This method is characterized in that sulfuryl chloride is added to and reacted with 2-halogeno-allylisothiocyanate represented by the formula (2): wherein Hal represents chlorine or bromine, while blowing a gas inactive to the reaction into the reaction liquid.
公开/授权文献
- US20100094022A1 Method for Producing Thiazole Compound 公开/授权日:2010-04-15
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