公开(公告)号：US08269044B2

公开(公告)日：2012-09-18

申请号：US12097234

申请日：2006-12-14

申请人： Naoyuki Takano ,  Kazuyuki Tanaka ,  Shinzo Seko

发明人： Naoyuki Takano ,  Kazuyuki Tanaka ,  Shinzo Seko

IPC分类号： C07D213/38 ,  C07D251/04 ,  C07C209/08

CPC分类号： C07C209/62 ,  C07C213/02 ,  C07D213/26 ,  C07D213/38 ,  C07D251/04 ,  C07C211/27 ,  C07C211/29 ,  C07C217/58

摘要： Disclosed is a method for producing a primary amine compound represented by the formula (3): wherein, Ar is as defined below, which is characterized in that a halogen compound represented by the formula (1): wherein, Ar represents an unsubstituted aromatic group such as a phenyl group, a naphthyl group, a pyridyl group, a furyl group, a thienyl group, a pyrrolyl group, an oxazolyl group, an isoxazolyl group or a pyrimidinyl group, or an aromatic group obtained by substituting such an unsubstituted aromatic group with 1-3 substituents; and X represents a halogen atom, ammonia and formaldehyde are reacted with each other, thereby obtaining a hexahydrotriazine compound represented by the formula (2): wherein, Ar is as defined above, and then the thus-obtained hexahydrotriazine compound is decomposed. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product.

摘要翻译： 公开了一种由式（3）表示的伯胺化合物的制备方法：其中Ar如下所定义，其特征在于由式（1）表示的卤素化合物：其中Ar表示未取代的芳族基团 苯基，萘基，吡啶基，呋喃基，噻吩基，吡咯基，恶唑基，异恶唑基或嘧啶基，或通过取代这些未取代的芳基取代的芳基 具有1-3个取代基; X表示卤素原子，氨和甲醛彼此反应，得到式（2）表示的六氢三嗪化合物：其中，Ar如上定义，然后将由此得到的六氢三嗪化合物分解。 通过这种方法，可以通过使用低成本氨同时抑制作为副产物的仲胺的生产，商业上有利地生产伯胺化合物。

公开(公告)号：US20090287023A1

公开(公告)日：2009-11-19

申请号：US12097974

申请日：2006-12-25

申请人： Hiroshi Souda ,  Naoyuki Takano ,  Shinzo Seko

发明人： Hiroshi Souda ,  Naoyuki Takano ,  Shinzo Seko

IPC分类号： C07C209/24

CPC分类号： C07C209/62 ,  C07C209/08 ,  C07C211/21 ,  C07C211/28

摘要： Disclosed is a method for producing a primary amine compound represented by the formula (2) below, which is characterized in that a halogen compound represented by the formula (1) below, ammonia and formaldehyde are reacted with each other, and then the thus-obtained reaction product is [1] brought into contact with an aqueous solution of an acid or [2] reacted with a hydroxylamine under acidic conditions. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product. (1) (In the formula, R1 and R2 independently represent a hydrogen atom, a C1-C5 alkyl group which may be substituted by a halogen atom or the like, a C1-C5 alkoxy group which may be substituted by a halogen atom, a cyano group, a C2-C11 alkenyl group or a phenyl group or the like; R3 represents a hydrogen atom, a linear or branched C1-C5 alkyl group or a cyano group; and X represents a halogen atom.) (2) (In the formula, R1, R2 and R3 are as defined above.)

摘要翻译： 公开了下述式（2）表示的伯胺化合物的制造方法，其特征在于，将下式（1）表示的卤素化合物与氨和甲醛反应， 得到的反应产物[1]在酸性条件下与酸的水溶液或[2]与羟胺反应。 通过这种方法，可以通过使用低成本氨同时抑制作为副产物的仲胺的生产，商业上有利地生产伯胺化合物。 （1）（式中，R 1和R 2各自独立地表示氢原子，可被卤素原子等取代的C1〜C5烷基，可被卤素原子取代的C1〜C5烷氧基， 氰基，C 2 -C 11烯基或苯基等; R 3表示氢原子，直链或支链C 1 -C 5烷基或氰基; X表示卤素原子）（2）（ 在式中，R 1，R 2和R 3如上所定义。）

公开(公告)号：US6114543A

公开(公告)日：2000-09-05

申请号：US128974

申请日：1998-08-04

申请人： Hideki Ushio ,  Naoyuki Takano ,  Yukihiro Honda ,  Shinzo Seko ,  Motoo Hazama

发明人： Hideki Ushio ,  Naoyuki Takano ,  Yukihiro Honda ,  Shinzo Seko ,  Motoo Hazama

IPC分类号： C07D205/04

CPC分类号： C07D205/04

摘要： The present invention provides a process for preparing optically active azetidine-2-carboxylic acids using readily available reagents of relatively low price in the industry. Thus, there is provided optically active azetidine-2-carboxylic acid, and a process for producing the same by subjecting optically active N-(alkylbenzyl)azetidine-2-carboxylic acid represented by the formula (1): ##STR1## to hydrogenolysis in the presence of a catalyst.

摘要翻译： 本发明提供了使用工业中价格相对较低的容易获得的试剂制备光学活性氮杂环丁烷-2-羧酸的方法。 因此，提供光学活性的氮杂环丁烷-2-羧酸及其制备方法，其中式（1）表示的光学活性的N-（烷基苄基）氮杂环丁烷-2-羧酸：在 催化剂

公开(公告)号：US5554317A

公开(公告)日：1996-09-10

申请号：US274315

申请日：1994-07-13

申请人： Yoshiaki Tsubata ,  Kayoko Ueda ,  Koichi Fujisawa ,  Takayuki Higashii ,  Masayoshi Minai ,  Naoyuki Takano ,  Yukari Fujimoto

发明人： Yoshiaki Tsubata ,  Kayoko Ueda ,  Koichi Fujisawa ,  Takayuki Higashii ,  Masayoshi Minai ,  Naoyuki Takano ,  Yukari Fujimoto

IPC分类号： C09K19/10 ,  C09K19/02 ,  C09K19/04 ,  C09K19/34 ,  C09K19/38 ,  C09K19/40 ,  C09K19/52 ,  C09K19/12 ,  G02F1/13

CPC分类号： C09K19/3469 ,  C09K19/0225 ,  C09K19/04 ,  C09K19/3857 ,  C09K19/3861 ,  C09K19/408

摘要： A compound having an unsaturated side chain represented by the formula: ##STR1## in which A and B are the same and different and represent an aromatic or heterocyclic group or either one of A and B represents a single bond; X.sub.1, X.sub.2 and X.sub.3 are the same or different and represent a hydrogen atom or a lower alkyl group; R.sub.1 represents a saturated or unsaturated alkyl group which may be substituted with a halogen atom or an alkoxyalkyl group which may be substituted with a halogen atom; X represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.ident.C-- or a single bond; n is an integer of 0 to 6; q is an integer of 1 to 15; p and s are each 0 or 1; and the asterisk * indicates an asymmetric carbon atom, which is useful as an intermediate of a liquid crystal or a monomer of a liquid crystalline polymer.

摘要翻译： 具有下式表示的不饱和侧链的化合物：其中A和B相同且不同，表示芳族或杂环基，或者A和B中的任一个表示单键; X 1，X 2和X 3相同或不同，表示氢原子或低级烷基; R1表示可以被卤素原子取代的饱和或不饱和的烷基或可被卤素原子取代的烷氧基烷基; X表示-CH 2 CH 2 - ， - CH = CH - ， - C = C-或单键; n为0〜6的整数。 q为1〜15的整数， p和s分别为0或1; 并且星号*表示不对称碳原子，其可用作液晶或液晶聚合物的单体的中间体。

公开(公告)号：US20100094022A1

公开(公告)日：2010-04-15

申请号：US12087587

申请日：2007-01-11

申请人： Naoyuki Takano ,  Morio Yamamoto ,  Shinzo Seko

发明人： Naoyuki Takano ,  Morio Yamamoto ,  Shinzo Seko

IPC分类号： C07D277/04

CPC分类号： C07D277/32

摘要： Disclosed is a simple and advantageous method for producing a thiazole compound, which method is suitable for commercial-scale implementation. In this method, a thiazole compound is produced by a reaction between 2-halogeno-allylisothiocyanate and sulfuryl chloride generating a large amount of heat, while suppressing decrease in the yield of the thiazole compound. Specifically disclosed is a method for producing 2-chloro-5-chloromethylthiazole represented by the formula (1): This method is characterized in that sulfuryl chloride is added to and reacted with 2-halogeno-allylisothiocyanate represented by the formula (2): wherein Hal represents chlorine or bromine, while blowing a gas inactive to the reaction into the reaction liquid.

摘要翻译： 本发明公开了一种生产噻唑化合物的简便有效的方法，该方法适用于商业规模的实施。 在该方法中，噻唑化合物通过2-卤代烯丙基异硫氰酸酯与磺酰氯的反应而产生，产生大量的热量，同时抑制噻唑化合物的产率降低。 具体公开的是式（1）表示的2-氯-5-氯甲基噻唑的制造方法：该方法的特征在于，向式（2）表示的2-卤代烯丙基异硫氰酸酯中加入磺酰氯，并与式 Hal代表氯或溴，同时向反应液中吹入无反应的气体。

公开(公告)号：US20090281325A1

公开(公告)日：2009-11-12

申请号：US12097234

申请日：2006-12-14

申请人： Naoyuki Takano ,  Kazuyuki Tanaka ,  Shinzo Seko

发明人： Naoyuki Takano ,  Kazuyuki Tanaka ,  Shinzo Seko

IPC分类号： C07D213/38 ,  C07C209/08

CPC分类号： C07C209/62 ,  C07C213/02 ,  C07D213/26 ,  C07D213/38 ,  C07D251/04 ,  C07C211/27 ,  C07C211/29 ,  C07C217/58

摘要： Disclosed is a method for producing a primary amine compound represented by the formula (3): wherein, Ar is as defined below , which is characterized in that a halogen compound represented by the formula (1): wherein, Ar represents an unsubstituted aromatic group such as a phenyl group, a naphthyl group, a pyridyl group, a furyl group, a thienyl group, a pyrrolyl group, an oxazolyl group, an isoxazolyl group or a pyrimidinyl group, or an aromatic group obtained by substituting such an unsubstituted aromatic group with 1-3 substituents; and X represents a halogen atom, ammonia and formaldehyde are reacted with each other, thereby obtaining a hexahydrotriazine compound represented by the formula (2): wherein, Ar is as defined above, and then the thus-obtained hexahydrotriazine compound is decomposed. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product.

摘要翻译： 公开了一种由式（3）表示的伯胺化合物的制备方法：其中Ar如下所定义，其特征在于由式（1）表示的卤素化合物：其中Ar表示未取代的芳族基团 苯基，萘基，吡啶基，呋喃基，噻吩基，吡咯基，恶唑基，异恶唑基或嘧啶基，或通过取代这些未取代的芳基取代的芳基 具有1-3个取代基; X表示卤素原子，氨和甲醛彼此反应，得到式（2）表示的六氢三嗪化合物：其中，Ar如上定义，然后将由此得到的六氢三嗪化合物分解。 通过这种方法，可以通过使用低成本氨同时抑制作为副产物的仲胺的生产，商业上有利地生产伯胺化合物。

公开(公告)号：US20080289720A1

公开(公告)日：2008-11-27

申请号：US12054273

申请日：2008-03-24

申请人： NAOYUKI TAKANO ,  Kazutoshi Sato ,  Kanji Omori

发明人： NAOYUKI TAKANO ,  Kazutoshi Sato ,  Kanji Omori

IPC分类号： B65B1/00

CPC分类号： F17C5/06 ,  F17C5/007 ,  F17C13/026 ,  F17C2221/012 ,  F17C2227/0341 ,  F17C2227/0355 ,  F17C2227/0365 ,  F17C2227/0388 ,  F17C2250/0439 ,  F17C2250/0631 ,  F17C2250/0636 ,  F17C2270/0139 ,  Y02E60/321 ,  Y02P90/45

摘要： A fuel filling apparatus is provided. The fuel filling apparatus comprises an overfilling protective valve arranged in a fuel gas supply path for supplying a fuel gas to an automobile. The overfilling protective valve further comprises a fuel gas path, a valve unit for opening and closing the fuel gas path by a valve body, a valve body displacement means for displacing the valve body according to a filling pressure of the fuel gas, and a temperature modulating unit for modulating a temperature of the valve body displacement means. Even though a difference between the temperature of the fuel gas and the operation temperature of the overfilling protective valve is large, the temperature of the valve body displacement means can be maintained within the preset temperature range by the temperature modulating unit and the overfilling protective valve can be exactly operated under the preset pressure.

摘要翻译： 提供了一种燃料充填装置。 燃料充填装置包括设置在用于向汽车供应燃料气体的燃料气体供给路径中的过充保护阀。 过充保护阀还包括燃料气路径，用于通过阀体打开和关闭燃料气体路径的阀单元，用于根据燃料气体的填充压力使阀体移位的阀体移动装置，以及温度 调节单元，用于调节阀体位移装置的温度。 即使燃料气体的温度与过充保护阀的运转温度之间的差异大，也可以通过温度调节单元将阀体移动装置的温度保持在预设的温度范围内，并且过充保护阀罐 在预设压力下精确运行。

公开(公告)号：US20070197803A1

公开(公告)日：2007-08-23

申请号：US11629754

申请日：2005-06-10

申请人： Naoyuki Takano ,  Shinzo Seko ,  Kazuyuki Tanaka

发明人： Naoyuki Takano ,  Shinzo Seko ,  Kazuyuki Tanaka

IPC分类号： C07D307/34

CPC分类号： C07D277/28

摘要： A process for preparing a thiazole compound of formula (3): wherein X1 represents a hydrogen atom or a halogen atom comprising reacting a compound of formula (1): wherein X1 is as defined above, and X2 represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of formula (2): wherein X1 is as defined above, and hydrolyzing the compound of formula (2).

摘要翻译： 制备式（3）的噻唑化合物的方法：其中X 1表示氢原子或卤素原子，包括使式（1）化合物：其中X 1〜 >如上所定义，X 2表示卤素原子，与氨和甲醛反应，得到式（2）的六氢三嗪化合物：其中X 1如上定义 ，并水解式（2）的化合物。

公开(公告)号：US20060089506A1

公开(公告)日：2006-04-27

申请号：US10549310

申请日：2004-03-24

申请人： Naoyuki Takano ,  Koji Hagiya

发明人： Naoyuki Takano ,  Koji Hagiya

IPC分类号： C07C69/74 ,  C07F9/94

CPC分类号： C07D317/54 ,  C07C45/30 ,  C07C67/333 ,  C07C69/757

摘要： There is provided a process for the production of carbonyl compounds, characterized by reacting a diol represented by the formula (1); wherein R1, R2, R3 and R4 are the same or different, and independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted alkoxycarbonyl group, a substituted or unsubstituted aryloxycarbonyl group, a substituted or unsubstituted aralkyloxycarbonyl group, carboxyl group or a hydrogen atom, or R1 and R2 or R3 and R4 are bonded together with the carbon atoms to which they are bonded to form a ring, provided that all of R1, R2, R3 and R4 are not hydrogen atoms simultaneously; with bromine or an inorganic bromine compound in the presence of a trivalent bismuth compound and a base to form carbonyl compounds represented by the formula (2); wherein R1 and R3 are as defined above; and the formula (3); wherein R2 and R4 are as defined above.

摘要翻译： 提供了一种制备羰基化合物的方法，其特征在于使由式（1）表示的二醇反应; 其中R 1，R 2，R 3和R 4相同或不同，并且独立地表示 取代或未取代的烷基，取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的酰基，取代或未取代的烷氧基羰基，取代或未取代的芳氧基羰基，取代或未取代的芳烷氧基羰基，羧基 或者氢原子，或者R 1和R 2或R 3和R 4是与 与它们键合的碳原子形成环，条件是R 1，R 2，R 3和R' 4不同时为氢原子; 与溴或无机溴化合物在三价铋化合物和碱的存在下反应形成由式（2）表示的羰基化合物; 其中R 1和R 3如上定义; 和式（3）; 其中R 2和R 4如上定义。

公开(公告)号：US5880291A

公开(公告)日：1999-03-09

申请号：US924320

申请日：1997-09-05

申请人： Hideki Ushio ,  Naoyuki Takano ,  Yukihiro Honda ,  Shinzo Seko ,  Motoo Hazama

发明人： Hideki Ushio ,  Naoyuki Takano ,  Yukihiro Honda ,  Shinzo Seko ,  Motoo Hazama

IPC分类号： C07D205/04

CPC分类号： C07D205/04

摘要： The present invention provides a process for preparing optically active azetidine-2-carboxylic acids using readily available reagents of relatively low price in the industry. Thus, there is provided optically active azetidine-2-carboxylic acid, and a process for producing the same by subjecting optically active N-(alkylbenzyl)azetidine-2-carboxylic acid represented by the formula (1): ##STR1## to hydrogenolysis in the presence of a catalyst.

摘要翻译： 本发明提供了使用工业中价格相对较低的容易获得的试剂制备光学活性氮杂环丁烷-2-羧酸的方法。 因此，提供光学活性的氮杂环丁烷-2-羧酸及其制备方法，该方法是使式（1）表示的旋光性N-（烷基苄基）氮杂环丁烷-2-羧酸：（1） 在催化剂存在下氢解。