发明授权
US08309315B2 Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
有权
在福尔马林固定和石蜡包埋组织中结合cMet（HGFR）的单克隆抗体及相关方法
- 专利标题： Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
- 专利标题（中）： 在福尔马林固定和石蜡包埋组织中结合cMet（HGFR）的单克隆抗体及相关方法
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申请号： US12679247申请日： 2008-08-25
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公开(公告)号： US08309315B2公开(公告)日： 2012-11-13
- 发明人: Boliang Cao , George F. Vande Woude , Beatrice S. Knudsen , Ping Xu Zhao
- 申请人： Boliang Cao , George F. Vande Woude , Beatrice S. Knudsen , Ping Xu Zhao
- 申请人地址： US MI Grand Rapids US WA Seattle
- 专利权人： Van Andel Research Institute,Fred Hutchinson Cancer Research Center
- 当前专利权人： Van Andel Research Institute,Fred Hutchinson Cancer Research Center
- 当前专利权人地址： US MI Grand Rapids US WA Seattle
- 代理机构： Honigman Miller Schwartz and Cohn LLP
- 代理商 Douglas H. Siegel
- 国际申请： PCT/US2008/074249 WO 20080825
- 国际公布： WO2009/029591 WO 20090305
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; C12N5/20 ; C12P21/08 ; G01N33/543 ; G01N33/554 ; G01N33/563 ; G01N33/574 ; G01N33/577
摘要：
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.
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