- 专利标题: Anti-CD19 antibodies
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申请号: US13398214申请日: 2012-02-16
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公开(公告)号: US08337840B2公开(公告)日: 2012-12-25
- 发明人: Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
- 申请人: Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
- 申请人地址: US NJ Morris Plains
- 专利权人: Immunomedics, Inc.
- 当前专利权人: Immunomedics, Inc.
- 当前专利权人地址: US NJ Morris Plains
- 代理商 Richard A. Nakashima
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/00
摘要:
The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various B-cell disorders, including B-cell malignancies and autoimmune diseases. In more particular embodiments, the humanized anti-CD19 antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. In a particularly preferred embodiment, the substitutions comprise a Ser91Phe substitution in the hA19 VH sequence.
公开/授权文献
- US20120189542A1 Anti-CD19 Antibodies 公开/授权日:2012-07-26
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