Invention Grant
US08338562B2 Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions
有权
用于纳米颗粒药物组合物的生物相容性，非生物降解性，无毒性聚合物
- Patent Title: Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions
- Patent Title (中): 用于纳米颗粒药物组合物的生物相容性，非生物降解性，无毒性聚合物
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Application No.: US12159310Application Date: 2006-12-26
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Publication No.: US08338562B2Publication Date: 2012-12-25
- Inventor: Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
- Applicant: Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
- Applicant Address: IN
- Assignee: Fresenius Kabi Oncology Limited
- Current Assignee: Fresenius Kabi Oncology Limited
- Current Assignee Address: IN
- Agency: Schwegman Lundberg & Woessner, P.A.
- Priority: IN1190/KOL/2005 20051228
- International Application: PCT/IN2006/000504 WO 20061226
- International Announcement: WO2007/074476 WO 20070705
- Main IPC: C08F26/00
- IPC: C08F26/00
Abstract:
The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.
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