发明授权
- 专利标题： Dual-acting pyrazole antihypertensive agents
- 专利标题（中）： 双效吡唑抗高血压药
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申请号： US13346237申请日： 2012-01-09
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公开(公告)号： US08350027B2公开(公告)日： 2013-01-08
- 发明人: Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- 申请人： Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- 申请人地址： US CA South San Francisco
- 专利权人： Theravance, Inc.
- 当前专利权人： Theravance, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah; Shelley Eberle
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; C07D401/14 ; C07D259/00 ; C07D271/06 ; C07D231/10
摘要：
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US20120259113A1 DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS 公开/授权日：2012-10-11
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