Invention Grant
US08354092B2 Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry
有权
使用点击化学开发碳酸酐酶IX的分子成像探针
- Patent Title: Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry
- Patent Title (中): 使用点击化学开发碳酸酐酶IX的分子成像探针
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Application No.: US12862955Application Date: 2010-08-25
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Publication No.: US08354092B2Publication Date: 2013-01-15
- Inventor: Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
- Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
- Applicant Address: US PA Malvern
- Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee Address: US PA Malvern
- Agent Joshua Ryan
- Main IPC: A61K51/00
- IPC: A61K51/00 ; C07D249/00 ; C07D343/00
Abstract:
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
Public/Granted literature
- US20100317842A1 Development of Molecular Imaging Probes for Carbonic Anhydrase-IX Using Click Chemistry Public/Granted day:2010-12-16
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