发明授权
US08354239B2 Fluorescent methods and materials for directed biomarker signal amplification
有权
用于定向生物标记信号放大的荧光方法和材料
- 专利标题: Fluorescent methods and materials for directed biomarker signal amplification
- 专利标题(中): 用于定向生物标记信号放大的荧光方法和材料
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申请号: US13195736申请日: 2011-08-01
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公开(公告)号: US08354239B2公开(公告)日: 2013-01-15
- 发明人: Brent S. Gaylord , Janice W. Hong , Tsu-Ju Fu , Cheng-Jun Sun , Russell Baldocchi
- 申请人: Brent S. Gaylord , Janice W. Hong , Tsu-Ju Fu , Cheng-Jun Sun , Russell Baldocchi
- 申请人地址: US CA San Diego
- 专利权人: Sirigen, Inc.
- 当前专利权人: Sirigen, Inc.
- 当前专利权人地址: US CA San Diego
- 代理机构: Wilson, Sonsini, Goodrich & Rosati
- 主分类号: G01N33/53
- IPC分类号: G01N33/53 ; G01N33/533 ; G01N21/76
摘要:
Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.