Invention Grant
US08357376B2 Method of purifying influenza virus and removing MDCK cell DNA contaminants
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净化流感病毒并去除MDCK细胞DNA污染物的方法
- Patent Title: Method of purifying influenza virus and removing MDCK cell DNA contaminants
- Patent Title (中): 净化流感病毒并去除MDCK细胞DNA污染物的方法
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Application No.: US12652557Application Date: 2010-01-05
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Publication No.: US08357376B2Publication Date: 2013-01-22
- Inventor: Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Jorge Camilo Maranga , Simon Sheng-Tsiung Hsu , Mridul Ghosh , Ajit Subramanian
- Applicant: Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Jorge Camilo Maranga , Simon Sheng-Tsiung Hsu , Mridul Ghosh , Ajit Subramanian
- Applicant Address: US MD Gaithersburg
- Assignee: Memimmune, LLC
- Current Assignee: Memimmune, LLC
- Current Assignee Address: US MD Gaithersburg
- Agency: Grant Anderson LLP
- Main IPC: A61K39/145
- IPC: A61K39/145
Abstract:
The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
Public/Granted literature
- US20100112669A1 MDCK CELLS LINES SUPPORTING VIRAL GROWTH TO HIGH TITERS AND BIOREACTOR PROCESS USING THE SAME Public/Granted day:2010-05-06
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