发明授权
- 专利标题： Biomimetic iron-oxide-containing lipoprotein and related materials
- 专利标题（中）： 含模拟氧化铁的脂蛋白及相关材料
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申请号： US12282308申请日： 2007-03-06
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公开(公告)号： US08361494B2公开(公告)日： 2013-01-29
- 发明人: I-Wei Chen , Hoon Choi
- 申请人： I-Wei Chen , Hoon Choi
- 申请人地址： US PA Philadelphia
- 专利权人： The Trustees Of The University of Pennsylvania
- 当前专利权人： The Trustees Of The University of Pennsylvania
- 当前专利权人地址： US PA Philadelphia
- 代理机构： RatnerPrestia
- 国际申请： PCT/US2007/063413 WO 20070306
- 国际公布： WO2007/106683 WO 20070920
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K49/18
摘要：
An engineered lipoprotein including (a) a core particle or a plurality of core particles, each core particle has (i) an inner part comprising a hydrophilic active agent and a hydrophilic portion of an amphiphilic cholesterol and (ii) an outer part including a hydrophobic portion of the amphiphilic cholesterol, (b) a layer surrounding the core particle or a plurality of core particles, the layer includes a phospholipid, (c) an apoprotein associated with the layer, and optionally, (d) a homing molecule associated with at least one of the apoprotein or the phospholipid.
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