Invention Grant
US08361959B2 Spiro-imidazolone derivatives as glucagon receptor antagonists
有权
螺 - 咪唑啉酮衍生物作为胰高血糖素受体拮抗剂
- Patent Title: Spiro-imidazolone derivatives as glucagon receptor antagonists
- Patent Title (中): 螺 - 咪唑啉酮衍生物作为胰高血糖素受体拮抗剂
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Application No.: US13121725Application Date: 2009-09-30
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Publication No.: US08361959B2Publication Date: 2013-01-29
- Inventor: Andrew Stamford , Michael W. Miller , Duane Eugene DeMong , William J. Greenlee , Joseph A. Kozlowski , Brian J. Lavey , Michael K. C. Wong , Wensheng Yu , Xing Dai , De-Yi Yang , Guowei Zhou
- Applicant: Andrew Stamford , Michael W. Miller , Duane Eugene DeMong , William J. Greenlee , Joseph A. Kozlowski , Brian J. Lavey , Michael K. C. Wong , Wensheng Yu , Xing Dai , De-Yi Yang , Guowei Zhou
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Anna L. Cocuzzo; Joan C. Todaro
- International Application: PCT/US2009/058963 WO 20090930
- International Announcement: WO2010/039789 WO 20100408
- Main IPC: A61F7/10
- IPC: A61F7/10 ; A61K31/4184 ; C07D235/02
Abstract:
The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
Public/Granted literature
- US20110178007A1 SPIRO-IMIDAZOLONE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS Public/Granted day:2011-07-21
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