发明授权
US08361959B2 Spiro-imidazolone derivatives as glucagon receptor antagonists
有权
螺 - 咪唑啉酮衍生物作为胰高血糖素受体拮抗剂
- 专利标题： Spiro-imidazolone derivatives as glucagon receptor antagonists
- 专利标题（中）： 螺 - 咪唑啉酮衍生物作为胰高血糖素受体拮抗剂
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申请号： US13121725申请日： 2009-09-30
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公开(公告)号： US08361959B2公开(公告)日： 2013-01-29
- 发明人: Andrew Stamford , Michael W. Miller , Duane Eugene DeMong , William J. Greenlee , Joseph A. Kozlowski , Brian J. Lavey , Michael K. C. Wong , Wensheng Yu , Xing Dai , De-Yi Yang , Guowei Zhou
- 申请人： Andrew Stamford , Michael W. Miller , Duane Eugene DeMong , William J. Greenlee , Joseph A. Kozlowski , Brian J. Lavey , Michael K. C. Wong , Wensheng Yu , Xing Dai , De-Yi Yang , Guowei Zhou
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Anna L. Cocuzzo; Joan C. Todaro
- 国际申请： PCT/US2009/058963 WO 20090930
- 国际公布： WO2010/039789 WO 20100408
- 主分类号： A61F7/10
- IPC分类号： A61F7/10 ; A61K31/4184 ; C07D235/02
摘要：
The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
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