发明授权
US08361993B2 Hydroxy-bisphosphonic acid derivatives as vector targeting bone tissue
有权
羟基 - 双膦酸衍生物作为靶向骨组织的载体
- 专利标题： Hydroxy-bisphosphonic acid derivatives as vector targeting bone tissue
- 专利标题（中）： 羟基 - 双膦酸衍生物作为靶向骨组织的载体
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申请号： US12811602申请日： 2009-01-05
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公开(公告)号： US08361993B2公开(公告)日： 2013-01-29
- 发明人: Maxim Egorov , Yannick Fortun , Dominique Heymann , Jacques Lebreton , Monique Mathe , Marc Padrines , Francoise Redini
- 申请人： Maxim Egorov , Yannick Fortun , Dominique Heymann , Jacques Lebreton , Monique Mathe , Marc Padrines , Francoise Redini
- 申请人地址： FR Nantes FR Paris FR Paris
- 专利权人： Universite de Nantes,Institut National de la Sante et de la Recherche Medicale (INSERM),Centre National de la Recherche Scientifique (CNRS)
- 当前专利权人： Universite de Nantes,Institut National de la Sante et de la Recherche Medicale (INSERM),Centre National de la Recherche Scientifique (CNRS)
- 当前专利权人地址： FR Nantes FR Paris FR Paris
- 代理机构： Foley & Lardner LLP
- 优先权： FR0850021 20080103
- 国际申请： PCT/EP2009/050027 WO 20090105
- 国际公布： WO2009/083614 WO 20090709
- 主分类号： A01N57/00
- IPC分类号： A01N57/00 ; A61K31/66 ; C07F9/02 ; C07F9/28
摘要：
The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: -n and m denote, independently of one another, an integer ranging from 1 to 4, —X denotes an oxygen atom or an N—R3 group, —R1 and R3 denote, independently of one another, a linear or branched C1 to C6 alkyl group, and —R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof.
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