公开(公告)号：US08361993B2

公开(公告)日：2013-01-29

申请号：US12811602

申请日：2009-01-05

申请人： Maxim Egorov ,  Yannick Fortun ,  Dominique Heymann ,  Jacques Lebreton ,  Monique Mathe ,  Marc Padrines ,  Francoise Redini

发明人： Maxim Egorov ,  Yannick Fortun ,  Dominique Heymann ,  Jacques Lebreton ,  Monique Mathe ,  Marc Padrines ,  Francoise Redini

IPC分类号： A01N57/00 ,  A61K31/66 ,  C07F9/02 ,  C07F9/28

CPC分类号： C07F9/3873 ,  C07F9/5728

摘要： The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: -n and m denote, independently of one another, an integer ranging from 1 to 4, —X denotes an oxygen atom or an N—R3 group, —R1 and R3 denote, independently of one another, a linear or branched C1 to C6 alkyl group, and —R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof.

摘要翻译： 本发明涉及对应于通式（I）的羟基 - 双膦酸衍生物：其中：-n和m彼此独立地表示1〜4的整数，-X表示氧原子或N- R3基团，-R1和R3彼此独立地表示直链或支链C1至C6烷基，-R2表示治疗或诊断兴趣的分子的残基或所述衍生物的药学上可接受的盐， 其制备方法及其治疗或诊断用途。

公开(公告)号：US20100311695A1

公开(公告)日：2010-12-09

申请号：US12811602

申请日：2009-01-05

申请人： Maxim Egorov ,  Yannick Fortun ,  Dominique Heymann ,  Jacques Lebreton ,  Monique Mathe ,  Marc Padrines ,  Francoise Redini

发明人： Maxim Egorov ,  Yannick Fortun ,  Dominique Heymann ,  Jacques Lebreton ,  Monique Mathe ,  Marc Padrines ,  Francoise Redini

IPC分类号： A61K31/663 ,  C07F9/38 ,  A61K31/664 ,  A61P35/00 ,  A61P19/00 ,  C12Q1/02

CPC分类号： C07F9/3873 ,  C07F9/5728

摘要： The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: -n and m denote, independently of one another, an integer ranging from 1 to 4, —X denotes an oxygen atom or an N—R3 group, —R1 and R3 denote, independently of one another, a linear or branched C1 to C6 alkyl group, and —R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof.

摘要翻译： 本发明涉及对应于通式（I）的羟基 - 双膦酸衍生物：其中：-n和m彼此独立地表示1〜4的整数，-X表示氧原子或N- R3基团，-R1和R3彼此独立地表示直链或支链C1至C6烷基，-R2表示治疗或诊断兴趣的分子的残基或所述衍生物的药学上可接受的盐， 其制备方法及其治疗或诊断用途。