发明授权
- 专利标题： Quinolone derivative
- 专利标题（中）： 喹诺酮衍生物
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申请号： US12680301申请日： 2008-09-25
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公开(公告)号： US08367702B2公开(公告)日： 2013-02-05
- 发明人: Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
- 申请人： Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
- 申请人地址： JP Tokyo
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权： JP2007-248877 20070926
- 国际申请： PCT/JP2008/067325 WO 20080925
- 国际公布： WO2009/041521 WO 20090402
- 主分类号： A61K31/04
- IPC分类号： A61K31/04 ; C07D215/38
摘要：
As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.
公开/授权文献
- US20100256113A1 QUINOLONE DERIVATIVE 公开/授权日：2010-10-07
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