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公开(公告)号:US08367702B2
公开(公告)日:2013-02-05
申请号:US12680301
申请日:2008-09-25
申请人: Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
发明人: Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
IPC分类号: A61K31/04 , C07D215/38
CPC分类号: C07D401/12 , C07D215/233 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/107
摘要: As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.
摘要翻译: 作为对NAD(P)H氧化酶抑制剂的广泛研究的结果,本发明人发现,在2位具有被杂原子等取代的烷基的喹诺酮衍生物具有优异的NAD(P)H氧化酶 抑制活性,完成了本发明。 本发明的化合物具有基于NAD(P)H氧化酶抑制活性的活性氧产生抑制活性,因此可用作糖尿病预防和/或治疗药物,糖耐量异常,高脂血症,脂肪肝 ,糖尿病并发症等。
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公开(公告)号:US20100256113A1
公开(公告)日:2010-10-07
申请号:US12680301
申请日:2008-09-25
申请人: Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
发明人: Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
IPC分类号: A61K31/4709 , C07D215/233 , C07D405/12 , C07D401/12 , C07D413/12 , A61K31/47 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/4725 , A61K31/55 , A61K31/553
CPC分类号: C07D401/12 , C07D215/233 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/107
摘要: As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.
摘要翻译: 作为对NAD(P)H氧化酶抑制剂的广泛研究的结果,本发明人发现,在2位具有被杂原子等取代的烷基的喹诺酮衍生物具有优异的NAD(P)H氧化酶 抑制活性,完成了本发明。 本发明的化合物具有基于NAD(P)H氧化酶抑制活性的活性氧产生抑制活性,因此可用作糖尿病预防和/或治疗药物,糖耐量异常,高脂血症,脂肪肝 ,糖尿病并发症等。
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