The present invention provides a method and system for mapping a reference signal sequence in an advanced Long Term Evolution (LTE) system, and the method and the system are used to map the reference signal sequence to an orthogonal frequency division multiplexing symbol of l. The method includes: when the system uses a normal cyclic prefix, determining the symbol l according to an expression, and mapping the reference signal sequence to a location of a sub-carrier k on the symbol l of an antenna port p. The system includes: a mapping module, a first acquiring module and a second acquiring module. The system and the method which are provided ensure the transmission performance while ensuring the interference randomization. In addition, the system and the method are compatible with existing LTE systems, thus realizing high-order Multiple Input Multiple Output (MIMO) transmission, supporting the usage of the corresponding techniques.