A system and method for remote direct memory access over a network switch fabric. Some illustrative embodiments may include a system comprising a first system node, a direct memory access (DMA) controller, a second system node, and a network switch fabric coupling together the first and second system nodes (the network switch fabric comprises a rooted hierarchical bus). The DMA controller is configured to perform a DMA transfer of data between the first and second system nodes across the network switch fabric. The data is formatted as one or more remote DMA (RDMA) protocol messages that are routed across the network switch fabric based on a bus end-device identifier corresponding to the second system node.