Invention Grant
US08377667B2 Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
有权
用于生产1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶A，腐胺及相关化合物的微生物及其相关方法
- Patent Title: Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
- Patent Title (中): 用于生产1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶A，腐胺及相关化合物的微生物及其相关方法
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Application No.: US13109732Application Date: 2011-05-17
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Publication No.: US08377667B2Publication Date: 2013-02-19
- Inventor: Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
- Applicant: Robert Haselbeck , John D. Trawick , Wei Niu , Anthony P. Burgard
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C12P7/02
- IPC: C12P7/02 ; C12N1/21 ; C12P21/00 ; C12N15/00 ; C12N9/02
Abstract:
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
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