发明授权
- 专利标题： Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
- 专利标题（中）： 嘧啶环戊烷作为AKT蛋白激酶抑制剂
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申请号： US12667850申请日： 2008-07-03
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公开(公告)号： US08377937B2公开(公告)日： 2013-02-19
- 发明人: Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Jun Liang , Brian S. Safina
- 申请人： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Jun Liang , Brian S. Safina
- 申请人地址： US CO Boulder US CA South San Francisco
- 专利权人： Array BioPharma Inc.,Genentech, Inc.
- 当前专利权人： Array BioPharma Inc.,Genentech, Inc.
- 当前专利权人地址： US CO Boulder US CA South San Francisco
- 代理机构： Viksnins Harris & Padys PLLP
- 国际申请： PCT/US2008/069147 WO 20080703
- 国际公布： WO2009/006569 WO 20090108
- 主分类号： C07D239/70
- IPC分类号： C07D239/70 ; A61K31/517
摘要：
The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
公开/授权文献
- US20110160221A1 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 公开/授权日：2011-06-30
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