Invention Grant
- Patent Title: Pyrazole-based thyroid receptor compounds
- Patent Title (中): 吡唑类甲状腺受体化合物
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Application No.: US13346968Application Date: 2012-01-10
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Publication No.: US08378118B2Publication Date: 2013-02-19
- Inventor: Laxmikant Chhipa , Shitalkumar Pukharaj Zambad , Ramesh Gupta , Davinder Tuli , Ashok Kasundra , Siralee Munshi , M. Amir Siddiqui , Subrat Kumar Bhattamisra , C. Dutt , Vijay Chauthaiwale
- Applicant: Laxmikant Chhipa , Shitalkumar Pukharaj Zambad , Ramesh Gupta , Davinder Tuli , Ashok Kasundra , Siralee Munshi , M. Amir Siddiqui , Subrat Kumar Bhattamisra , C. Dutt , Vijay Chauthaiwale
- Applicant Address: IN Gujarat State
- Assignee: Torrent Pharmaceuticals Ltd.
- Current Assignee: Torrent Pharmaceuticals Ltd.
- Current Assignee Address: IN Gujarat State
- Agency: Jacobson Holman PLLC
- Priority: IN857/KOL/2007 20070606
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/415 ; A61K31/4155 ; A61K31/4245 ; A61K31/506 ; C07D231/20 ; C07D403/06 ; C07D403/04 ; C07D413/04 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P3/00 ; A61P5/14 ; A61P17/00 ; A61P9/00 ; A61P25/24

Abstract:
The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.
Public/Granted literature
- US20120202816A1 NOVEL COMPOUNDS Public/Granted day:2012-08-09
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