公开(公告)号：US08541430B2

公开(公告)日：2013-09-24

申请号：US12877704

申请日：2010-09-08

申请人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

发明人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： C07D513/04 ,  C07D513/14

摘要： The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

摘要翻译： 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。

公开(公告)号：US20110130414A1

公开(公告)日：2011-06-02

申请号：US12877704

申请日：2010-09-08

申请人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

发明人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07D471/14 ,  A61P9/00 ,  A61P13/12 ,  A61P31/00 ,  A61P35/00 ,  A61P7/06

CPC分类号： C07D513/04 ,  C07D513/14

摘要： The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

摘要翻译： 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。

公开(公告)号：US08143424B2

公开(公告)日：2012-03-27

申请号：US12224168

申请日：2008-06-02

申请人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  Chaitanya Dutt ,  Vijay Chauthaiwale

发明人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  Chaitanya Dutt ,  Vijay Chauthaiwale

IPC分类号： A61K31/5377 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/506 ,  C07D231/20 ,  C07D403/06 ,  C07D403/04 ,  C07D413/04 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/00 ,  A61P5/14 ,  A61P17/00 ,  A61P9/00 ,  A61P25/24

CPC分类号： C07D403/06 ,  C07D231/12 ,  C07D231/14 ,  C07D231/18 ,  C07D403/10 ,  C07D403/12 ,  C07D409/04 ,  C07D413/06

摘要： A novel thyroid like compounds of formula (I), wherein R1, R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition and use thereof. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions including obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.

摘要翻译： 一种新型甲状腺类似式（I）的化合物，其中R1，R2，R3，R4和Z如说明书中所定义，其制备方法，组合物和用途。 此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。 本发明还涉及式（I）化合物在制备用于治疗各种疾病状况，包括肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。

公开(公告)号：US20120202816A1

公开(公告)日：2012-08-09

申请号：US13346968

申请日：2012-01-10

申请人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

发明人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

IPC分类号： A61K31/415 ,  C07D403/06 ,  A61K31/4155 ,  C07D409/04 ,  C07D413/06 ,  A61K31/4245 ,  C07D413/04 ,  A61K31/5377 ,  A61P3/04 ,  A61P5/48 ,  A61P3/10 ,  A61P3/06 ,  A61P3/00 ,  A61P5/14 ,  A61P3/08 ,  A61P25/24 ,  A61P9/00 ,  A61P17/00 ,  C07D231/18

CPC分类号： C07D403/06 ,  C07D231/12 ,  C07D231/14 ,  C07D231/18 ,  C07D403/10 ,  C07D403/12 ,  C07D409/04 ,  C07D413/06

摘要： The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.

摘要翻译： 本发明公开了一种新颖的甲状腺样化合物，其中R1 R2，R3，R4和Z如本说明书中所定义，其制备方法，含有这些化合物的组合物以及这些化合物的用途和作为药物的组合物。 此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。 本发明还涉及式（I）化合物在制备用于治疗各种疾病状况如肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。

公开(公告)号：US08378118B2

公开(公告)日：2013-02-19

申请号：US13346968

申请日：2012-01-10

申请人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

发明人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

IPC分类号： A61K31/5377 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/506 ,  C07D231/20 ,  C07D403/06 ,  C07D403/04 ,  C07D413/04 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/00 ,  A61P5/14 ,  A61P17/00 ,  A61P9/00 ,  A61P25/24

CPC分类号： C07D403/06 ,  C07D231/12 ,  C07D231/14 ,  C07D231/18 ,  C07D403/10 ,  C07D403/12 ,  C07D409/04 ,  C07D413/06

摘要： The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.

摘要翻译： 本发明公开了一种新颖的甲状腺样化合物，其中R1 R2，R3，R4和Z如本说明书中所定义，其制备方法，含有这些化合物的组合物以及这些化合物的用途和组合物作为药物。 此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。 本发明还涉及式（I）化合物在制备用于治疗各种疾病状况如肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。

公开(公告)号：US20100168110A1

公开(公告)日：2010-07-01

申请号：US12224168

申请日：2008-06-02

申请人： Laxmikant Chhipa ,  Shitalkumar Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

发明人： Laxmikant Chhipa ,  Shitalkumar Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

IPC分类号： A61K31/5377 ,  C07D231/20 ,  A61K31/415 ,  C07D403/06 ,  A61K31/4155 ,  C07D403/04 ,  C07D413/04 ,  A61K31/4245 ,  A61K31/506 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/00 ,  A61P5/14 ,  A61P17/00 ,  A61P9/00 ,  A61P25/24

CPC分类号： C07D403/06 ,  C07D231/12 ,  C07D231/14 ,  C07D231/18 ,  C07D403/10 ,  C07D403/12 ,  C07D409/04 ,  C07D413/06

摘要： The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.

摘要翻译： 本发明公开了一种新颖的甲状腺样化合物，其中R1 R2，R3，R4和Z如本说明书中所定义，其制备方法，含有这些化合物的组合物以及这些化合物的用途和组合物作为药物。 此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。 本发明还涉及式（I）化合物在制备用于治疗各种疾病状况如肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。